Although morphine is widely used in clinical treatment of pain, the mechanism of the analgesic central spinal cord is unclear. Most of the existing research focuses on the changes of nerve activity after morphine suppresses pain. Few studies have reported that morphine regulates the activity of central neurons under painless conditions, and the latter is precisely the basis of advanced analgesia in surgery. The so-called advanced analgesia refers to the administration of analgesic drugs before surgery to suppress the sensitization process of the noxious system. Compared with conventional postoperative administration, preoperative administration can more effectively relieve postoperative pain and reduce Demand for analgesic drugs. The mechanism of preemptive analgesia is unclear so far. Therefore, revealing the regulation of morphine on the spontaneous activity of the thalamic-cortical pain sensory neural network helps to understand the mechanism of preemptive analgesia of morphine.
The Luo Fei research group of the Key Laboratory of Mental Health of the Chinese Academy of Sciences has carried out related research on this issue. In this study, adult rats were used as the research object. Awake animal single neuron multi-channel simultaneous recording technology was used to investigate the pain sensory pathway (primary somatosensory cortex and thalamus ventrolateral nucleus) and emotional pathway in the painless state of morphine alone (Anterior cingulate gyrus and dorsal medial nucleus of thalamus) Regulation of spontaneous activity of neurons and functional connections between brain regions. The results showed that morphine medication caused a change in the spontaneous activity of 1/3 of the recorded neurons. For pain sensory pathways, morphine mainly produces excitement, while for emotion pathways, morphine produces dual effects of excitement and inhibition, that is, the activity of some neurons is excited while the activity of another part of neurons is inhibited. In addition, after morphine administration, the functional connection of the thalamic-cortical area in the pain neural network was significantly inhibited, which showed that the neuron's interaction-related activities were significantly weakened.
These results indicate that the regulation of morphine on pain neural network (excitation / inhibition coexistence) in resting state is different from that in pain state (full inhibition), which may be that the analgesic effect is better than real-time analgesia. Where the mechanism is.
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