On October 10, the research team of Professor Zhang Xiaokun, an expert of the “Thousand Talents Program†of Xiamen University School of Pharmacy, published an important research paper in the internationally renowned oncology journal Oncogene. This research was conducted in cooperation with the research group of academician Yao Xinsheng, a famous natural product research expert in China. It made a new exploration of the mechanism and treatment of colon cancer, and discovered potential therapeutic targets and inhibitors for tumor cell growth. drug.
β-catenin is a multifunctional protein, its main function is to mediate cell adhesion and participate in the regulation of gene expression, and its expression is closely regulated by APC and other related proteins; recent studies have shown that due to APC and its related genes The mutation that leads to abnormal accumulation of β-catenin is closely related to the occurrence of colon cancer. Therefore, looking for a new APC-independent β-catenin expression regulation pathway is extremely important for the treatment of colon cancer. The study found that the orphan nuclear receptor Nur77 can negatively regulate the expression of β-catenin through its non-genotypic function, thereby inhibiting the growth of tumor cells. At the same time, the study also found two cardiac glycoside compounds that can negatively regulate the expression of β-catenin by inducing the expression of Nur77: H-9 and ATE-i2-b4. The study proves that Nur77 can be used as a potential target for colon cancer treatment at the molecular, cellular and animal levels, and H-9 and ATE-i2-b4 may become potential drugs for the treatment of colon cancer.
The first author of the paper is Sun Zhe, a doctoral student at the School of Pharmacy, Xiamen University; the corresponding authors are Professor Zhang Xiaokun and Academician Yao Xinsheng. In recent years, Professor Zhang Xiaokun and his research group have achieved many major achievements in the field of cancer research. They have published many papers in the international high-level journals with Xiamen University as the first or corresponding author unit. The magazine includes Cancer Cell (JCR Area 1) , Impact factor 26.925), Cancer Res (JCR first area, impact factor 8.234), FASEB J (JCR second area, impact factor 6.515), Oncogene (JCR first area, impact factor 7.414), etc. These innovative discoveries have very important theoretical and practical significance for humans to overcome cancer.
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